Virchows Archiv

, Volume 452, Issue 4, pp 443–448

Delta-like protein (DLK) is a novel immunohistochemical marker for human hepatoblastomas

  • Katalin Dezső
  • Judit Halász
  • Hanne Cathrine Bisgaard
  • Sándor Paku
  • Eszter Turányi
  • Zsuzsa Schaff
  • Peter Nagy
Original Article

DOI: 10.1007/s00428-007-0571-8

Cite this article as:
Dezső, K., Halász, J., Bisgaard, H.C. et al. Virchows Arch (2008) 452: 443. doi:10.1007/s00428-007-0571-8

Abstract

Delta-like protein (DLK) is a membrane protein with mostly unknown function. It is expressed by several embryonic tissues among others by the hepatoblasts of rodent and human fetal livers. We have investigated in the present study if this protein is expressed in human hepatoblastomas. The presence of DLK has been studied by standard immunohistochemistry in 31 hepatoblastomas and in several differential diagnostically related tumours: hepatocellular carcinomas and in undifferentiated childhood neoplasms. All the hepatoblastomas were positive for DLK; the surrounding liver tissue remained negative. The reaction was present in the epithelial component of the tumours. The staining pattern was mostly membranous, occasionally cytoplasmic. The other studied tumours were negative for DLK, except one hepatocellular carcinoma and the differentiating cells of two ganglioneuroblastomas. Therefore, DLK seems to be a highly sensitive and specific marker for hepatoblastomas.

Keywords

Immunohistochemistry Hepatoblastoma DLK 

Abbreviations

DLK

delta-like protein

AFP

alpha-fetoprotein

TLCT

transitional liver cell tumour

MPNST

malignant peripheral nerve sheath tumour

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Katalin Dezső
    • 1
  • Judit Halász
    • 2
  • Hanne Cathrine Bisgaard
    • 3
  • Sándor Paku
    • 1
  • Eszter Turányi
    • 1
  • Zsuzsa Schaff
    • 2
  • Peter Nagy
    • 1
  1. 1.First Department of Pathology and Experimental Cancer ResearchSemmelweis UniversityBudapestHungary
  2. 2.Second Department of PathologySemmelweis UniversityBudapestHungary
  3. 3.The Danish Stem Cell Research Centre, Department of Cellular and Molecular Medicine, The Panum InstituteUniversity of CopenhagenCopenhagenDenmark

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