Virchows Archiv

, Volume 451, Issue 5, pp 923–928

Myxoinflammatory fibroblastic sarcoma: investigations by comparative genomic hybridization of two cases and review of the literature

Authors

    • Institute of PathologyUniversity of Basel
  • Kathrin Glatz
    • Institute of PathologyUniversity of Basel
  • Hans-Jürgen Schulten
    • Department of PathologyUniversity of Göttingen
  • László Füzesi
    • Department of PathologyUniversity of Göttingen
  • Renato Fricker
    • Department of SurgeryKantonsspital Bruderholz
  • Christoph Kettelhack
    • Department of SurgeryUniversity of Basel
  • Paula Hasenboehler
    • Department of SurgeryBethesda Spital
  • Martin Oberholzer
    • Institute of PathologyUniversity of Basel
  • Gernot Jundt
    • Institute of PathologyUniversity of Basel
    • Bone Tumor Reference Center at the Institute of PathologyUniversity of Basel
Original Article

DOI: 10.1007/s00428-007-0480-x

Cite this article as:
Baumhoer, D., Glatz, K., Schulten, H. et al. Virchows Arch (2007) 451: 923. doi:10.1007/s00428-007-0480-x

Abstract

Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare low-grade sarcoma of the distal extremities characterized by a myxohyaline stroma, a dense inflammatory infiltrate and virocyte- and lipoblast-like giant cells. Up to now, only two cases have been investigated cytogenetically, showing complex and heterogeneous karyotypes, in part with supernumerary ring chromosomes. We characterized two further cases of MIFS immunohistochemically and performed comparative genomic hybridization as well as DNA image cytometry analyses. Both tumors showed the characteristic histomorphological pattern of MIFS and were positive for Vimentin and CD68. Moreover, both cases presented aberrant karyotypes including distinct DNA copy number changes involving chromosome 7 and disclosed DNA aneuploidy.

Keywords

Myxoinflammatory fibroblastic sarcomaComparative genomic hybridizationCGHDNA image cytometryReview

Copyright information

© Springer-Verlag 2007