, Volume 450, Issue 5, pp 607-609
Date: 12 Apr 2007

A novel myoepithelial/progenitor cell marker in the breast?

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access
This is an excerpt from the content

Dear Editor,

Neuroepithelial stem cell protein (Nestin) is an intermediate filament (IF) protein considered to be a marker of neural stem cells. Nestin expression has been confirmed in stem/progenitor cells of the dermis, hair follicles, intestine, pancreas, bone marrow as well as in neural, muscle and other tissues (reviewed in [7]). Its expression is down regulated in the course of differentiation and subsequently replaced by another type of IF [3, 10]. Nestin expression has also been detected in the endothelium [11, 12], and we have noted the activation of nestin expression in newly formed human blood vessels [7]. The human nestin molecule has a homology with rodent nestin confirming its highly conserved nature (Fig. 2c) [5].

The myoepithelial cells of the breast form an outer layer of the terminal duct lobular unit. They play an active part in mammary gland branching morphogenesis [6], and their correct recognition and detection is crucial in the diagnosis of a number of pathological ...