Virchows Archiv

, Volume 449, Issue 5, pp 561–564

Anaplastic large-cell non-Hodgkin’s lymphoma of the breast in periprosthetic localisation 32 years after treatment for primary breast cancer—a case report

  • Florian Rudolf Fritzsche
  • Stefan Pahl
  • Iver Petersen
  • Mick Burkhardt
  • Anja Dankof
  • Manfred Dietel
  • Glen Kristiansen
Case Report

DOI: 10.1007/s00428-006-0287-1

Cite this article as:
Fritzsche, F.R., Pahl, S., Petersen, I. et al. Virchows Arch (2006) 449: 561. doi:10.1007/s00428-006-0287-1

Abstract

Primary, as well as secondary, lymphomas of the breast are rare diseases and might, in some cases, be misdiagnosed as breast cancer on routine hematoxylin/eosin stainings. We report a case of an anaplastic large cell lymphoma in a 72-year-old woman with a history of breast cancer treated with breast-ablative surgery and a subsequent silicon implant 32 years ago. Clinically, she presented with an ulceration of the skin, which had developed within a few months. On conventional histology, the tumor cells were mimicking poorly differentiated invasive ductal carcinoma with a prominent leukocytic infiltrate. The immunoprofile of the tumor showed negativity for cytokeratins and led to the diagnosis of a CD30-positive anaplastic large cell lymphoma.

Keywords

LymphomaBreast cancerALCLC-ALCLImmunohistochemistry

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Florian Rudolf Fritzsche
    • 1
  • Stefan Pahl
    • 1
  • Iver Petersen
    • 1
  • Mick Burkhardt
    • 1
  • Anja Dankof
    • 1
  • Manfred Dietel
    • 1
  • Glen Kristiansen
    • 1
  1. 1.Institute of PathologyCharité Universitätsmedizin BerlinBerlinGermany