Virchows Archiv

, Volume 449, Issue 3, pp 376–381

Tumor of the liver (hepatocellular and high grade neuroendocrine carcinoma): a case report and review of the literature

  • Monica T. Garcia
  • Pablo A. Bejarano
  • Maria Yssa
  • Efren Buitrago
  • Alan Livingstone
Case Report

DOI: 10.1007/s00428-006-0251-0

Cite this article as:
Garcia, M.T., Bejarano, P.A., Yssa, M. et al. Virchows Arch (2006) 449: 376. doi:10.1007/s00428-006-0251-0

Abstract

We describe a rare hepatic collision tumor composed of a hepatocellular carcinoma and a high-grade neuroendocrine carcinoma. The patient, a 50-year-old man, underwent a partial hepatectomy because of a 5.0-cm mass. The tumor had two distinctive patterns. The majority of the tumor was a high-grade neuroendocrine carcinoma with features of a small cell carcinoma that was positive for chromogranin, synaptophysin, and cytokeratin 19 and negative for hepatocellular antigen and alpha-fetoprotein (AFP). The second component was a moderately differentiated hepatocellular carcinoma that was positive for hepatocellular antigen and AFP and negative for neuroendocrine markers. The two tumors were separated by fibrous bands. In areas where they collided, there was no transition or intermingling of cells between the two components, thus, it is different from the combined type of tumors. After removal of the tumor, the patient had intrahepatic and mesenteric recurrences within a follow-up period of 16 months.

Keywords

Collision tumor Combined tumor Liver neoplasms 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Monica T. Garcia
    • 1
  • Pablo A. Bejarano
    • 1
  • Maria Yssa
    • 1
  • Efren Buitrago
    • 2
  • Alan Livingstone
    • 2
  1. 1.Department of PathologyUniversity of Miami, Miller School of Medicine--Jackson Memorial HospitalMiamiUSA
  2. 2.Department of SurgeryUniversity of Miami, Miller School of MedicineMiamiUSA

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