Virchows Archiv

, Volume 449, Issue 2, pp 159–163

Preinvasive intraductal neoplasia in salivary adenocarcinoma, not otherwise specified


    • Institute of PathologyLudwig Maximilian University
  • Andrea Sendelhofert
    • Institute of PathologyLudwig Maximilian University
  • Christoph Weiler
    • Institute of PathologyLudwig Maximilian University
  • Hjalmar Hagedorn
    • Department of ENT, Head and Neck SurgeryLudwig Maximilian University
  • John D. Harrison
    • Department of Oral Pathology, King’s College London Dental Institute at Guy’sKing’s College and St. Thomas’ Hospitals
Original Article

DOI: 10.1007/s00428-006-0208-3

Cite this article as:
Ihrler, S., Sendelhofert, A., Weiler, C. et al. Virchows Arch (2006) 449: 159. doi:10.1007/s00428-006-0208-3


Preinvasive intraductal neoplasia of the salivary glands has only been identified in the rare salivary-duct carcinoma, whereas, it is an established feature of carcinomas of other glands. A fortuitous observation of what appeared to be intraductal tumor in a salivary adenocarcinoma, not otherwise specified, led to the present investigation to determine whether intraductal neoplasia is a significant feature of this carcinoma. Intraductal tumor confined by normal CK14-positive, actin-negative ductal basal cells was identified in 15 of 22 cases (68%). The degree of cellular atypia and the pattern of growth of intraductal tumor was similar to that of the invasive tumor. Cases with intraductal tumor devoid of invasive tumor were not found. Intraductal tumor is identified as the pre-invasive precursor of adenocarcinoma, not otherwise specified, and apparently develops in excretory ducts. The findings support the possibility that different salivary tumors arise from different types of parenchymal cell. Possibly intraductal neoplasia is a universal feature of many types of salivary tumor, but has been overlooked because of the need to use immunohistology to demonstrate it and because it may no longer be present as such when the tumor presents as a clinical lesion.


Salivary gland Carcinogenesis Immunohistochemistry

Copyright information

© Springer-Verlag 2006