Virchows Archiv

, Volume 448, Issue 4, pp 517–520

α-fetoprotein expression in a dedifferentiated liposarcoma

  • Martino Bosco
  • Elena Allia
  • Jean-Michel Coindre
  • Chiara Odasso
  • Alberto Pagani
  • Donatella Pacchioni
Case Report

DOI: 10.1007/s00428-006-0151-3

Cite this article as:
Bosco, M., Allia, E., Coindre, JM. et al. Virchows Arch (2006) 448: 517. doi:10.1007/s00428-006-0151-3

Abstract

Extremely rare cases of paraneoplastic syndromes or ectopic production of proteins associated with liposarcoma are reported in literature. We describe a unique case of relapsing retroperitoneal dedifferentiated liposarcoma with biochemical, immunohistochemical, and molecular evidence of alpha-fetoprotein (AFP) ectopic production. The lesion was associated to elevated AFP plasma levels that subsided after tumor removal. Immunohistochemical studies showed AFP production by a minority of tumor cells and reverse transcriptase polymerase chain reaction confirmed AFP mRNA expression. Finding of MDM2 and CDK4 iperexpression by immunohistochemistry confirmed the diagnosis of dedifferentiated liposarcoma.

Keywords

Dedifferentiated liposarcoma Alpha-fetoprotein Ectopic production 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Martino Bosco
    • 1
  • Elena Allia
    • 1
  • Jean-Michel Coindre
    • 2
  • Chiara Odasso
    • 3
  • Alberto Pagani
    • 4
  • Donatella Pacchioni
    • 1
  1. 1.Department of Biomedical Sciences and Human OncologyUniversity of TurinTurinItaly
  2. 2.Department of PathologyInstitut BergoniéBordeauxFrance
  3. 3.Department of General SurgeryUniversity of TurinTurinItaly
  4. 4.Department of PathologyOspedale Civile di PineroloPineroloItaly

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