Virchows Archiv

, Volume 446, Issue 5, pp 542–545

Adenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum

  • M. Vieth
  • R. Kushima
  • J. P. A. de Jonge
  • F. Borchard
  • F. Oellig
  • M. Stolte
Case Report

DOI: 10.1007/s00428-005-1242-2

Cite this article as:
Vieth, M., Kushima, R., de Jonge, J.P.A. et al. Virchows Arch (2005) 446: 542. doi:10.1007/s00428-005-1242-2

Abstract

In a 46-year-old man, a pedunculated rectal polyp measuring 3.0×3.0×2.0 cm was diagnosed histologically as a pyloric gland-type adenoma arising in heterotopic gastric corpus mucosa. The luminal site was covered by glands of the gastric foveolar type, displaying focal marked proliferation interpreted as low-grade intraepithelial neoplasia. A bidirectional gastric differentiation was found: most lower glandular structures showed positivity for the deep gastric mucin core protein Muc 6 and superficial positivity for gastric foveolar epithelium mucin core protein Muc 5AC. Pyloric gland adenoma has so far been described in one larger series only and a few case reports of the stomach, gallbladder, pancreatic duct and within heterotopic gastric corpus mucosa of the duodenal bulb. The present case report is the first case of a pyloric gland-type adenoma within a gastric corpus heterotopia of the rectal mucosa.

Keywords

Pyloric-gland adenomaRectum polypHeterotopic gastric mucosa

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • M. Vieth
    • 1
  • R. Kushima
    • 2
  • J. P. A. de Jonge
    • 3
  • F. Borchard
    • 4
  • F. Oellig
    • 1
  • M. Stolte
    • 1
  1. 1.Institute of PathologyKlinikum BayreuthBayreuthGermany
  2. 2.Department of Clinical Science and Laboratory Medicine, Division of Diagnostic PathologyShiga University of Medical ScienceOhtsuJapan
  3. 3.Institute of Pathology, NordhornNordhornGermany
  4. 4.Institute of PathologyKlinikum AschaffenburgAschaffenburgGermany