Virchows Archiv

, Volume 446, Issue 5, pp 555–559

“Sugar” tumor of the pancreas: a rare entity that is diagnosable on preoperative fine-needle biopsies

  • Olivier Ramuz
  • Bernard Lelong
  • Marc Giovannini
  • Jean-Robert Delpero
  • Philippe Rochaix
  • Luc Xerri
  • Jacques Hassoun
  • Jean-François Flejou
  • Geneviève Monges
Case Report

DOI: 10.1007/s00428-005-1216-4

Cite this article as:
Ramuz, O., Lelong, B., Giovannini, M. et al. Virchows Arch (2005) 446: 555. doi:10.1007/s00428-005-1216-4

Abstract

This study is the second to report a pancreatic “sugar” tumor (ST) case. This ST was incidentally discovered in a 31-year-old woman using computed tomography scan (CT scan) for work-up of a hepatic focal nodular hyperplasia. Both CT scan and endoluminal ultrasonography (EUS) features evoked a 15-mm large benign endocrine tumor. Pathological examination of EUS-guided fine-needle aspiration biopsies could not confirm this diagnosis. Laparoscopic corporeo-caudal pancreatectomy was performed. The tumor was intrapancreatic, well circumscribed, and organized in sheets of epithelioid cells. The tumor cells expressed HMB-45 but did not express epithelial or endocrine immunohistochemical markers. These histophenotypic features are those of an extra pulmonary ST, which belong to the PEComa family of tumors. Retrospective examination of preoperative biopsies evidenced the same histophenotypic features. This observation highlights that STs should be considered in preoperative differential diagnosis of pancreas tumors, since they may be treated by limited surgical resection.

Keywords

“Sugar” tumorPEComaPancreasImmunohistochemistryMelanoma markersFine-needle aspirationEndoluminal ultrasonography

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Olivier Ramuz
    • 1
  • Bernard Lelong
    • 2
  • Marc Giovannini
    • 3
  • Jean-Robert Delpero
    • 2
  • Philippe Rochaix
    • 4
  • Luc Xerri
    • 1
  • Jacques Hassoun
    • 1
  • Jean-François Flejou
    • 5
  • Geneviève Monges
    • 1
  1. 1.Department of PathologyInstitut Paoli-CalmettesMarseilleFrance
  2. 2.Department of Surgical OncologyInstitut Paoli-CalmettesMarseilleFrance
  3. 3.Department of Medical OncologyInstitut Paoli-CalmettesMarseilleFrance
  4. 4.Department of PathologyInstitut Claudius RegaudToulouseFrance
  5. 5.Department of PathologyHôpital Saint-AntoineParisFrance