Virchows Archiv

, Volume 446, Issue 5, pp 546–554

Interdigitating dendritic cell tumor with breast and cervical lymph-node involvement: a case report and review of the literature

  • Ömer Uluoğlu
  • Nalan Akyürek
  • Aytuğ Üner
  • Uğur Coşkun
  • Ayşegul Özdemir
  • Nahide Gökçora
Case Report

DOI: 10.1007/s00428-005-1209-3

Cite this article as:
Uluoğlu, Ö., Akyürek, N., Üner, A. et al. Virchows Arch (2005) 446: 546. doi:10.1007/s00428-005-1209-3

Abstract

Interdigitating dendritic cell tumor (IDCT) is an extremely rare malignancy. It occurs primarily in lymph nodes, but extranodal involvement has also been reported. A 38-year-old woman with IDCT with breast and cervical lymph-node involvement is reported in this paper. To our knowledge, this is the first case of IDCT originating from the breast. In the breast and lymph node, the tumor displayed diffuse sheets, fascicles and storiform growth pattern. It was composed of oval to spindle cells with pale to eosinophilic cytoplasm, ill-defined cell outlines, oval nuclei with vesicular chromatin and prominent eosinophilic nucleoli. Mitotic activity was three per ten high-power fields. The neoplastic cells were intermingled with small mature lymphocytes and plasma cells. Immunohistochemical studies showed that the tumor cells were strongly and diffusely positive for vimentin, CD68, S-100 protein, CD45/leukocyte common antigen and fascin and focally positive for lysozyme, alpha-1 antitrypsin and CD4. Ki-67 labeling index was 10%. The patient was treated with combined therapeutic approaches, including surgery, radiotherapy and chemotherapy. IDCT has the potential for an aggressive clinical course. However, 32 months after the initial diagnosis, the patient is still alive and being followed with a stable tumor burden.

Keywords

Interdigitating dendritic cell tumor Breast Prognosis Immunohistochemistry 

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Ömer Uluoğlu
    • 1
  • Nalan Akyürek
    • 1
    • 5
  • Aytuğ Üner
    • 2
  • Uğur Coşkun
    • 2
  • Ayşegul Özdemir
    • 3
  • Nahide Gökçora
    • 4
  1. 1.Department of PathologyGazi University Medical SchoolAnkaraTurkey
  2. 2.Department of Medical OncologyGazi University Medical SchoolAnkaraTurkey
  3. 3.Department of RadiologyGazi University Medical SchoolAnkaraTurkey
  4. 4.Department of Nuclear MedicineGazi University Medical SchoolAnkaraTurkey
  5. 5.Dikmen-AnkaraTurkey