Virchows Archiv

, Volume 446, Issue 5, pp 537–541

Pyloric gland adenoma arising in Barrett’s esophagus with mucin immunohistochemical and molecular cytogenetic evaluation

Authors

    • Division of Diagnostic PathologyShiga University of Medical Science
  • Michael Vieth
    • Institute of PathologyKlinikum Bayreuth
  • Ken-ichi Mukaisho
    • Department of PathologyShiga University of Medical Science
  • Rie Sakai
    • Division of Diagnostic PathologyShiga University of Medical Science
  • Hidetoshi Okabe
    • Division of Diagnostic PathologyShiga University of Medical Science
  • Takanori Hattori
    • Department of PathologyShiga University of Medical Science
  • Horst Neuhaus
    • Department of General Internal MedicineEvangelisches Krankenhaus Düsseldorf
  • Franz Borchard
    • Institute of PathologyKlinikum Aschaffenburg
  • Manfred Stolte
    • Institute of PathologyKlinikum Bayreuth
Case Report

DOI: 10.1007/s00428-004-1185-z

Cite this article as:
Kushima, R., Vieth, M., Mukaisho, K. et al. Virchows Arch (2005) 446: 537. doi:10.1007/s00428-004-1185-z

Abstract

Pyloric gland adenoma is a recently described and very rare entity. The occurrence of adenoma is very unusual in Barrett’s epithelium of the esophagus. We report a case of esophageal polyp showing the features of pyloric gland adenoma, which was surrounded by so-called specialized columnar epithelium. Immunohistochemically, most tumor glands were strongly positive for MUC6, except in the superficial layer. MUC5AC was positive in almost all tumor cells, but MUC2 and CD10 were negative in the tumor. MIB-1-positive proliferating cells were distributed throughout the tumor. Microdissection and comparative genomic hybridization analyses revealed losses on 2p24–25.2, 2q14.1-ter, 5q31.3–32, 6q23–24, 8q23–24.2, 11q22.3–24 and 18q21.1–22. This is the first case of pyloric gland adenoma found to arise in Barrett’s epithelium of the esophagus, showing its unstable and precancerous nature.

Keywords

Pyloric gland adenomaBarrett’s epitheliumEsophagusMucinCGH

Copyright information

© Springer-Verlag 2005