Virchows Archiv

, Volume 445, Issue 6, pp 641–646

Malignant transformation of sialadenoma papilliferum of the palate: a case report

  • Masayuki Shimoda
  • Kaori Kameyama
  • Shojiroh Morinaga
  • Youichi Tanaka
  • Kazuhiro Hashiguchi
  • Megumi Shimada
  • Yasunori Okada
Case Report

DOI: 10.1007/s00428-004-1091-4

Cite this article as:
Shimoda, M., Kameyama, K., Morinaga, S. et al. Virchows Arch (2004) 445: 641. doi:10.1007/s00428-004-1091-4

Abstract

We report a case of a 79-year-old woman with an unusual salivary gland tumor that developed at the junction between the soft and hard palates. The tumor consisted of sialadenoma papilliferum (SP) with areas of an epithelial–myoepithelial carcinoma (EMC) component and a high-grade carcinoma component. There were also transitional regions among the SP, the EMC and the high-grade carcinoma components. The high-grade carcinoma component, which was similar to invasive micropapillary carcinoma of the breast, infiltrated into the right parapharyngeal space and metastasized to the lungs and cervical vertebrae. The high-grade carcinoma cells were positively immunostained for p53 protein. SP has been considered to be a benign tumor with exceptionally good prognosis, and, to the best of our knowledge, there has never been a confirmed case of malignant SP. This is the first report of SP with a definite malignant component.

Keywords

Sialadenoma papilliferumEpithelial–myoepithelial carcinomaHigh-grade carcinomap53

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Masayuki Shimoda
    • 1
  • Kaori Kameyama
    • 2
  • Shojiroh Morinaga
    • 3
  • Youichi Tanaka
    • 4
  • Kazuhiro Hashiguchi
    • 5
  • Megumi Shimada
    • 6
  • Yasunori Okada
    • 1
  1. 1.Department of PathologySchool of Medicine, Keio UniversityTokyoJapan
  2. 2.Division of Diagnostic PathologyKeio University HospitalTokyoJapan
  3. 3.Division of Diagnostic PathologyKitasato Institute HospitalTokyoJapan
  4. 4.Division of Surgical PathologyTokyo Dental College Ichikawa General HospitalChibaJapan
  5. 5.Division of OtorhinolaryngologyKitasato Institute HospitalTokyoJapan
  6. 6.Division of Internal MedicineKitasato Institute HospitalTokyoJapan