Virchows Archiv

, Volume 445, Issue 3, pp 315–319

Haemangiopericytoma of the thyroid gland in combination with Hashimoto’s disease

  • T. Hansen
  • A. Gaumann
  • M. Ghalibafian
  • A. Höferlin
  • A. Heintz
  • C. J. Kirkpatrick
Case Report

DOI: 10.1007/s00428-004-1066-5

Cite this article as:
Hansen, T., Gaumann, A., Ghalibafian, M. et al. Virchows Arch (2004) 445: 315. doi:10.1007/s00428-004-1066-5

Abstract

We present a hitherto unique case of haemangiopericytoma (HP) of the thyroid gland in a 15-year-old female patient suffering from Hashimoto’s disease for several months. Since angiogenesis has been discussed to play a major role in both diseases, we examined the expression of vascular endothelial growth factor (VEGF), VEGF receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs). Most interestingly, strong expression of PDGFR α and β was found in spindle-shaped tumour cells and tumour vessels in HP, while VEGF and VEGFR type I and -II were negative in these regions. In contrast, VEGF was expressed in the lymphoid infiltrate of Hashimoto’s disease. Since PDGFR-β is commonly expressed in pericytes, we suggest that the strong expression discovered in this study further supports the view that HP is derived from pericytes. The combination of HP and Hashimoto’s disease is most probably a coincidental event. However, this case confirms previous reports demonstrating that in patients with Hashimoto’s disease different neoplasias can occur.

Keywords

HaemangiopericytomaHashimoto’s diseasePericytePDGF receptorVEGF receptor

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • T. Hansen
    • 1
  • A. Gaumann
    • 2
  • M. Ghalibafian
    • 1
  • A. Höferlin
    • 3
  • A. Heintz
    • 3
  • C. J. Kirkpatrick
    • 1
  1. 1.Institute of PathologyJohannes Gutenberg, University of MainzMainzGermany
  2. 2.Institute of PathologyUniversity of RegensburgGermany
  3. 3.Department of SurgerySt. Hildegardis HospitalMainzGermany