Virchows Archiv

, Volume 445, Issue 1, pp 63–67

CDX-2, cytokeratin 7 and cytokeratin 20 immunohistochemical expression in the differential diagnosis of primary adenocarcinomas of the sinonasal tract

  • A. Franchi
  • D. Massi
  • A. Palomba
  • M. Biancalani
  • M. Santucci
Original Article

DOI: 10.1007/s00428-004-1030-4

Cite this article as:
Franchi, A., Massi, D., Palomba, A. et al. Virchows Arch (2004) 445: 63. doi:10.1007/s00428-004-1030-4
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Abstract

Because the histopathological features of some primary adenocarcinomas of the sinonasal tract may show considerable overlap, we assessed the diagnostic value of a panel of immunohistochemical markers in the distinction between these malignancies. Paraffin-embedded tumour tissue sections from a series of 39 primary adenocarcinomas of the sinonasal tract, including 25 cases of intestinal-type adenocarcinoma (ITAC), 10 cases of salivary gland-type carcinoma and 4 cases of tubulopapillary low-grade adenocarcinoma were immunostained for CDX-2, cytokeratin 7 and cytokeratin 20. Diffuse nuclear staining for CDX-2 was identified in 80% of ITACs, while all non-ITACs were negative. Staining for cytokeratin 20 was positive in 84% of ITACs, including all cases negative for CDX-2, but negative in all other adenocarcinomas. Cytokeratin 7 was consistently positive in 88% of ITACs and in 100% of non-ITACs. Normal sinonasal epithelia expressed cytokeratin 7, but not CDX-2 and cytokeratin 20. Staining for CDX-2 and cytokeratin 20 has potential use in separating ITACs from other primary malignant glandular neoplasms of the nasal cavities and paranasal sinuses.

Keywords

Nasal cavity Paranasal sinuses Intestinal-type adenocarcinoma Salivary gland-type carcinoma Low-grade adenocarcinoma 

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • A. Franchi
    • 1
    • 3
  • D. Massi
    • 1
  • A. Palomba
    • 2
  • M. Biancalani
    • 2
  • M. Santucci
    • 1
  1. 1.Department of Human Pathology and OncologyUniversity of FlorenceItaly
  2. 2.Division of Anatomic Pathology, Department of Laboratory Medicine“S. Giuseppe” HospitalEmpoliItaly
  3. 3.Department of Human Pathology and OncologyUniversity of Florence Medical SchoolFlorenceItaly