, Volume 444, Issue 6, pp 594-596
Date: 30 Apr 2004

Gastrointestinal stromal tumor: report of two unusual cases

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Sir, Gastrointestinal stromal tumor (GIST) is a neoplasm with recently established diagnostic criteria (immunoreactivity to CD117). The most common anatomical site of GIST occurrence is the stomach, followed by small bowel and colon [1]. Despite the term gastrointestinal, they have also been reported in extraintestinal sites, such as the omentum, retroperitoneum and mesentery. We present two cases of tumors arising from unusual sites, one from the retroperitoneum and one from the pancreas, with the latter representing the first report in the literature of a GIST in such a topography.

The first case concerns a 48-year-old female patient who had a mass on her left hypochondrium detected on a routine evaluation. Radiological follow-up revealed progressive growth, and a laparotomy was performed. At operation, the tumor was located between the stomach and spleen. Adhesions with these organs were present, more pronounced in the spleen. The mass was resected en bloc with the spleen and a gastr ...