Virchows Archiv

, Volume 443, Issue 6, pp 734–740

Reproducibility of the 1998 World Health Organization/International Society of Urologic Pathology classification of papillary urothelial neoplasms of the urinary bladder

Authors

    • School of Medicine, Department of PathologyDokuz Eylul University
  • Burcin Tuna
    • School of Medicine, Department of PathologyDokuz Eylul University
  • Emel Dikicioglu
    • School of Medicine, Department of PathologyAdnan Menderes University
  • Ender Duzcan
    • School of Medicine, Department of PathologyPamukkale University
  • Aydin Isisag
    • School of Medicine, Department of PathologyCelal Bayar University
  • Sait Sen
    • School of Medicine, Department of PathologyEge University
  • Ugur Mungan
    • School of Medicine, Department of UrologyDokuz Eylul University
  • Ziya Kirkali
    • School of Medicine, Department of UrologyDokuz Eylul University
Original Article

DOI: 10.1007/s00428-003-0905-0

Cite this article as:
Yorukoglu, K., Tuna, B., Dikicioglu, E. et al. Virchows Arch (2003) 443: 734. doi:10.1007/s00428-003-0905-0

Abstract

Objectives

This study assessed the diagnostic agreement and intra- and inter-observer reproducibility of the World Health Organization/International Society of Urologic Pathology Consensus Classification of Urothelial Neoplasms (1998 WHO/ISUP classification) and the 1973 WHO classification.

Methods

A teaching set with 5 slides of each papillary neoplasm of low malignant potential, low-grade papillary carcinoma, high-grade papillary carcinoma, and a guideline, as well as a study set of 30 slides containing ten cases of each category, were sent to participants. Six pathologists expert in urological pathology reviewed the 30 slides of non-invasive papillary urothelial tumors in the study set. Diagnostic accuracy and reproducibility were evaluated using intra- and inter-rater techniques (kappa statistic).

Results

A moderate to substantial intra- and inter-observer reproducibility was achieved for both the 1998 WHO/ISUP and 1973 WHO classification. The results of the two classification systems were not different statistically (P>0.05). Reproducibility was lower in low-grade tumors for both classifications.

Conclusions

The new proposed classification system for non-invasive urothelial neoplasms does not increase the reproducibility. There is still a need for uniformity in grading in order to compare the different studies and therapies and to provide more accurate information for management.

Keywords

Bladder neoplasmsUrotheliumWorld Health OrganizationClassification

Copyright information

© Springer-Verlag 2003