Orginal Article

Virchows Archiv

, Volume 440, Issue 6, pp 594-597

Expression of cyclo-oxygenase-2 in human tongue carcinoma and its precursor lesions

  • Jutta RenkonenAffiliated withTransplantation Laboratory, Haartman Institute and Helsinki University Central Hospital, P.O. Box 21, Haartmaninkatu 3, 00014 Helsinki, Finland
  • , Henrik WolffAffiliated withPathology Laboratory, Finnish Institute of Occupational Health, Topeliuksenkatu 41, 00250 Helsinki, Finland
  • , Timo PaavonenAffiliated withDepartment of Pathology, Haartman Institute and Helsinki University Central Hospital, P.O. Box 400, Haartmaninkatu 3, 00029 Helsinki, Finland

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The expression of Cox-2 protein was studied by immunohistochemistry in normal oral mucosa and in mucosa with various lesions of oral leukoplakia, including hyperplasia and dysplasia of squamous epithelium and frank invasive squamous carcinoma. A gradient of Cox-2 staining was found: the expression of Cox-2 was lowest in normal epithelium, somewhat increased in hyperplastic epithelium, further increased in dysplastic epithelium, and highest in invasive squamous cell carcinomas. The presence of Cox-2 in squamous cell carcinomas of the oral mucosa and its precursor lesions indicate that Cox-2 could participate in the carcinogenic process of these oral malignancies.

Cyclo-oxygenase-2 Oral dysplasia Oral carcinoma Carcinogenesis Immunohistochemistry Leukoplakia