Virchows Archiv

, Volume 440, Issue 6, pp 594–597

Expression of cyclo-oxygenase-2 in human tongue carcinoma and its precursor lesions

  • Jutta Renkonen
  • Henrik Wolff
  • Timo Paavonen
Orginal Article

DOI: 10.1007/s00428-002-0616-y

Cite this article as:
Renkonen, J., Wolff, H. & Paavonen, T. Virchows Arch (2002) 440: 594. doi:10.1007/s00428-002-0616-y


The expression of Cox-2 protein was studied by immunohistochemistry in normal oral mucosa and in mucosa with various lesions of oral leukoplakia, including hyperplasia and dysplasia of squamous epithelium and frank invasive squamous carcinoma. A gradient of Cox-2 staining was found: the expression of Cox-2 was lowest in normal epithelium, somewhat increased in hyperplastic epithelium, further increased in dysplastic epithelium, and highest in invasive squamous cell carcinomas. The presence of Cox-2 in squamous cell carcinomas of the oral mucosa and its precursor lesions indicate that Cox-2 could participate in the carcinogenic process of these oral malignancies.

Cyclo-oxygenase-2 Oral dysplasia Oral carcinoma Carcinogenesis Immunohistochemistry Leukoplakia

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Jutta Renkonen
    • 1
  • Henrik Wolff
    • 3
  • Timo Paavonen
    • 2
  1. 1.Transplantation Laboratory, Haartman Institute and Helsinki University Central Hospital, P.O. Box 21, Haartmaninkatu 3, 00014 Helsinki, FinlandFinland
  2. 2.Department of Pathology, Haartman Institute and Helsinki University Central Hospital, P.O. Box 400, Haartmaninkatu 3, 00029 Helsinki, FinlandFinland
  3. 3.Pathology Laboratory, Finnish Institute of Occupational Health, Topeliuksenkatu 41, 00250 Helsinki, FinlandFinland
  4. 4.Department of Pathology, Kymenlaakso Central Hospital, Kotkantie 41, 48210 Kotka, FinlandFinland