Virchows Archiv

, Volume 440, Issue 4, pp 418–424

Diffuse (or multinodular) follicular variant of papillary thyroid carcinoma: a clinicopathologic and immunohistochemical analysis of ten cases of an aggressive form of differentiated thyroid carcinoma

  • Radina Ivanova
  • Paula Soares
  • Patrícia Castro
  • Manuel Sobrinho-Simões
Original Article

DOI: 10.1007/s00428-001-0543-3

Cite this article as:
Ivanova, R., Soares, P., Castro, P. et al. Virchows Arch (2002) 440: 418. doi:10.1007/s00428-001-0543-3

Abstract

In an attempt to advance and improve the characterization of the so-called diffuse follicular variant of papillary thyroid carcinoma (diffuse FVPTC) we studied a series of 59 thyroid carcinomas consecutively treated in a specialized center. The clinicopathologic and some of the immunohistochemical characteristics (uPA-R, Lewis X, Sialyl Lewis X, and MIB-1) of ten cases of FVPTC displaying a multinodular or diffuse pattern of growth, and histologic features similar to those previously described in diffuse FVPTC, were compared with those of common papillary thyroid carcinoma (PTC, 25 cases) and common FVPTC (8 cases). Cases of diffuse FVPTC differed significantly from common PTC and FVPTC in targeting younger patients and in exhibiting a prevalence of multicentricity, extrathyroid extension, nodal metastasis, and vascular invasion. Immunohistochemically, diffuse FVPTC cases were characterized by the overexpression of uPAR and sialyl Lewis X. No differences were observed regarding MIB 1 immunoreactivity. Regardless of the term used to designate the multicentric, invasive form of FVPTC (diffuse or multinodular FVPTC) it is crucial to acknowledge the existence of cases of FVPTC with a guarded prognosis that should be distinguished from the classic, uninodular form of FVPTC.

Papillary thyroid carcinoma Diffuse follicular variant uPA-R Lewis X Sialyl Lewis X MIB-1 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Radina Ivanova
    • 1
  • Paula Soares
    • 2
  • Patrícia Castro
    • 2
  • Manuel Sobrinho-Simões
    • 2
  1. 1.Laboratory of Pathomorphology, Clinical Center of Endocrinology, Medical University, SofiaBulgaria
  2. 2.Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Dr. Roberto Frias s/n, 4200 PortoPortugal
  3. 3.Department of Pathology, Medical Faculty of Porto, Porto, PortugalPortugal

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