Development Genes and Evolution

, Volume 208, Issue 8, pp 431–439

Conservation of BF-1 expression in amphioxus and zebrafish suggests evolutionary ancestry of anterior cell types that contribute to the vertebrate telencephalon

  • Håkan Toresson
  • Juan Pedro Martinez-Barbera
  • Anne Bardsley
  • Xavier Caubit
  • S. Krauss
ORIGINAL ARTICLE

DOI: 10.1007/s004270050200

Cite this article as:
Toresson, H., Martinez-Barbera, J., Bardsley, A. et al. Dev Gene Evol (1998) 208: 431. doi:10.1007/s004270050200

Abstract

 The forkhead domain containing transcription factor BF-1 has been shown to play a major role in the correct development of the cerebral hemispheres in the mouse. BF-1 orthologs have been isolated from zebrafish and the cephalocordate amphioxus. In both species, BF-1 is expressed in the anterior neural tube. In zebrafish zBF-1 expression is restricted to anterior portions of the otic vesicle and to the presumptive telencephalon. In amphioxus AmphiBF-1 is transiently seen in the frontal part of the first somite and, at 3 days of development, in a small number of cells in the cerebral vesicle (cv). The anterior expression of BF-1 in chordates and vertebrates and of slp-1/2 in Drosophila suggests that BF-1 is crucial for an evolutionarily conserved specification of anterior neuronal cell types.

Key words AmphioxusZebrafishBF-1SomitesTelencephalon

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Håkan Toresson
    • 1
  • Juan Pedro Martinez-Barbera
    • 1
  • Anne Bardsley
    • 1
  • Xavier Caubit
    • 2
  • S. Krauss
    • 2
  1. 1.Developmental Biology Unit, Department of Cell and Molecular Biology, Lund University, S-22362 Lund, SwedenSE
  2. 2.Department of Molecular Genetics, Institute of Medical Biology, N-9037 Tromsø, NorwayNO