Development Genes and Evolution

, Volume 207, Issue 1, pp 65–70

The chicken NKX2.8 homeobox gene: A novel member of the NK-2 gene family

Authors

  • Thomas Boettger
    • Max-Planck-Institut für biophysikalische Chemie, Am Fassberg, D-37077 Göttingen, Germany
  • Stefan Stein
    • Max-Planck-Institut für biophysikalische Chemie, Am Fassberg, D-37077 Göttingen, Germany
  • M. Kessel
    • Max-Planck-Institut für biophysikalische Chemie, Am Fassberg, D-37077 Göttingen, Germany
ORIGINAL ARTICLE

DOI: 10.1007/s004270050092

Cite this article as:
Boettger, T., Stein, S. & Kessel, M. Dev Gene Evol (1997) 207: 65. doi:10.1007/s004270050092

Abstract

 We have isolated the chicken homeobox gene NKX2.8, which represents a novel member of the NK-2 gene family. Besides the homeodomain, the NKX2.8 protein contains two other conserved sequences, a TN and an NK2 domain. NKX2.8 is expressed in the ventral foregut, the developing heart, in the epithelial layers of the branchial arches and in the dorsal mesocardium. Thus, its expression overlaps partially, but also differs significantly from another chicken tinman orthologue, the NKX2.5 gene. It is suggestive that NKX2.8 and NKX2.5 play a cooperative role in early heart development.

Key words NK-2 homeobox tinman Heart Branchial arch Chicken

Copyright information

© Springer-Verlag Berlin Heidelberg 1997