Development Genes and Evolution

, Volume 206, Issue 6, pp 363–369

Distribution of Pax6 protein during eye development suggests discrete roles in proliferative and differentiated visual cells

  • Rachel Macdonald
  • S. W. Wilson

DOI: 10.1007/s004270050065

Cite this article as:
Macdonald, R. & Wilson, S. Dev Gene Evol (1997) 206: 363. doi:10.1007/s004270050065


 Although Pax6 is required during eye development in rodents and humans, little is known about the precise role of the protein in this process. To aid in the interpretation of functional studies, we have determined the precise spatial and temporal distributions of the Pax6 protein in the eye. We find that Pax6 is initially distributed contiguously throughout a large domain of the anterior neural plate of zebrafish, including the presumptive eye fields and the dorsal diencephalon. After evagination of the optic vesicle, Pax6 becomes restricted to all proliferating cells of the pigment epithelial and neural layers of the retina. Pax6 is downregulated in most cells concomitant with differentiation. However, it remains present in several mature cell types of the eye including amacrine cells and the lens and corneal epithelia. This expression is conserved across diverse vertebrate species and suggests that Pax6 has additional conserved functions in the mature eye.

Key words Zebrafish Paired box pax6 Eye development Neuronal differentiation 

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Rachel Macdonald
    • 1
  • S. W. Wilson
    • 1
  1. 1.Developmental Biology Research Centre, Randall Institute, Kings College London, 26-29 Drury Lane, London WC2B 5RL, UKGB

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