Development Genes and Evolution

, Volume 217, Issue 10, pp 715–723

The basic helix-loop-helix transcription factor family in Bombyx mori

  • Yong Wang
  • Keping Chen
  • Qin Yao
  • Wenbing Wang
  • Zhi Zhu
Short Communication

DOI: 10.1007/s00427-007-0184-x

Cite this article as:
Wang, Y., Chen, K., Yao, Q. et al. Dev Genes Evol (2007) 217: 715. doi:10.1007/s00427-007-0184-x

Abstract

The basic helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that play important roles in a wide range of developmental processes in higher organisms. bHLH family members have been identified in a dozen of organisms including fruit fly, mouse and human. We identified 52 bHLH members in silico in the silkworm genome. Phylogenetic analyses revealed that they belong to 39 bHLH families with 21, 10, 12, 1, 7 and 1 members in groups A, B, C, D, E and F, respectively. Genes that encode ASCb, NeuroD, Oligo, MyoRb, Figα and Mad were not found in the silkworm genome. The present study provides important background information for future studies using the silkworm as a model system for insect development. Besides, the in-group phylogenetic analysis was demonstrated to be effective in classifying identified bHLH sequences into corresponding families, which can be helpful in the classification of bHLH members of other organisms.

Keywords

Basic helix-loop-helix Transcription factor Bombyx mori Phylogeny Genome searching Blast search 

Abbreviations

ASC

Achaete–Scute complex

Ngn

neurogenin

H/E(spl)

Hairy/E(spl)

Hs

Homo sapien (human)

Mm

Mus musculus (mouse)

Bf

Branchiostoma floridae (the Florida lancelet)

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Yong Wang
    • 1
  • Keping Chen
    • 2
  • Qin Yao
    • 2
  • Wenbing Wang
    • 2
  • Zhi Zhu
    • 1
  1. 1.Department of Biotechnology, Faculty of Food and Biological EngineeringJiangsu UniversityZhenjiangPeople’s Republic of China
  2. 2.Institute of Life SciencesJiangsu UniversityZhenjiangPeople’s Republic of China

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