Development Genes and Evolution

, Volume 217, Issue 6, pp 413–420

Both Hoxc13 orthologs are functionally important for zebrafish tail fin regeneration

Authors

    • Department of Molecular and Integrative PhysiologyUniversity of Kansas Medical Center
    • Center for Zebrafish Research and Department of Biological SciencesUniversity of Notre Dame
  • Mila Ju
    • Department of Anatomy and Cell BiologyUniversity of Kansas Medical Center
  • Michael P. SarrasJr.
    • Department of Anatomy and Cell BiologyUniversity of Kansas Medical Center
    • Department of Cell Biology and AnatomyRosalind Franklin University of Medicine and Science
  • Alan R. Godwin
    • Department of Molecular and Integrative PhysiologyUniversity of Kansas Medical Center
Original Article

DOI: 10.1007/s00427-007-0154-3

Cite this article as:
Thummel, R., Ju, M., Sarras, M.P. et al. Dev Genes Evol (2007) 217: 413. doi:10.1007/s00427-007-0154-3

Abstract

Hox genes are re-expressed during regeneration in many species. Given their important role in body plan development, it has been assumed, but not directly shown, that they play a functional role in regeneration. In this paper we show that morpholino-mediated knockdown of either Hoxc13a or Hoxc13b during the process of zebrafish tail fin regeneration results in a significant reduction of regenerative outgrowth. Furthermore, cellular proliferation within the blastema is directly affected in both knockdowns. Hence, similar to the demonstration of unique functions of multiple Hox genes during limb formation, both Hoxc13 orthologs have distinct functions in regeneration.

Keywords

HoxRegenerationMorpholinoElectroporationZebrafish

Copyright information

© Springer-Verlag 2007