Development Genes and Evolution

, Volume 214, Issue 5, pp 211–219

Expression of the telomeric retrotransposon HeT-A in Drosophila melanogaster is correlated with cell proliferation

Original Article

DOI: 10.1007/s00427-004-0400-x

Cite this article as:
Walter, M.F. & Biessmann, H. Dev Genes Evol (2004) 214: 211. doi:10.1007/s00427-004-0400-x


Drosophila melanogaster extends its telomeres by transposition of two non-LTR retrotransposons, HeT-A and TART, to chromosome ends. We have determined the tissue-specific expression of these two elements by whole-mount in situ hybridization with digoxigenin-labeled RNA sense and antisense probes in the germ line and in a variety of larval tissues during normal development in the wild type and in tissues of mutants that cause overproliferation. Our results indicate that transcript levels, which are a key component in the process of telomere elongation in D. melanogaster, are correlated with cell proliferation in normal tissues and that RNA levels are elevated in growth-stimulated tissues.


DrosophilaTelomereHeT-A retrotransposonCell proliferationRNA expression

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Developmental Biology CenterUniversity of CaliforniaIrvineUSA