, Volume 213, Issue 5, pp 667–681

Regulatory network of tetrapyrrole biosynthesis – studies of intracellular signalling involved in metabolic and developmental control of plastids

  • Jutta Papenbrock
  • Bernhard Grimm

DOI: 10.1007/s004250100593

Cite this article as:
Papenbrock, J. & Grimm, B. Planta (2001) 213: 667. doi:10.1007/s004250100593


Plant tetrapyrrole metabolism is located in two different organelles and distributes end products into the whole cell. A complex regulatory network is involved to prevent metabolic imbalance and inefficient allocation of intermediates as well as to correlate the metabolic activities with organelle development. This review presents new findings about the control of tetrapyrrole biosynthesis and addresses the question of which regulatory principles are involved in controlling the expression of the participating enzymes and the metabolic flow in the entire pathway. It is suggested that functional organelles are required for nuclear gene expression and that metabolic signals participate in a signalling cascade transferring information from plastids to the nucleus. Recent reports about plastid-localised control mechanisms for plant tetrapyrrole metabolism are summarised and compared with results obtained in experiments on nucleus-plastid communication.

Chlorophyll Chloroplast Feedback Heme Porphyrin 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Jutta Papenbrock
    • 1
  • Bernhard Grimm
    • 2
  1. 1.Institut für Botanik, Universität Hannover, Herrenhäuser Str. 2, 30419 Hannover, Germany
  2. 2.Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK), Corrensstr. 3, 06466 Gatersleben, Germany
  3. 3.Present address: Institut für Biologie/Pflanzenphysiologie, Humboldt Universität zu Berlin (Sitz Philippstr. 13, Haus 12), Unter den Linden 6, 10099 Berlin, Germany, e-mail:, Fax: +49-30-20936337