Pflügers Archiv

, Volume 443, Supplement 1, pp S85–S91

cAMP signaling cascades and CFTR: is there more to learn?

  • Neil A. Bradbury
Article

DOI: 10.1007/s004240100651

Cite this article as:
Bradbury, N.A. Pflügers Arch - Eur J Physiol (2001) 443(Suppl 1): S85. doi:10.1007/s004240100651

Abstract.

CFTR is an apically resident ion channel whose activity is regulated by the activation of the cAMP mediated second messenger cascade. As depicted in textbooks, the cAMP mediated signaling cascade appears deceptively simple, yet, our growing understanding of this pathway shows it to be much more complicated and finely tuned than originally thought. The intent of this review is to evaluate our current understanding of the cAMP mediated signaling as it relates to the secretion of mucin and chloride, two compounds whose regulated secretion is altered in cystic fibrosis.

AKAP Chloride Cystic Fibrosis CFTR cAMP Mucin PKA

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Neil A. Bradbury
    • 1
  1. 1.S306 BST South, Dept. Cell Biology and Physiology, 3500 Terrace Street, University of Pittsburgh School of Medicine, Pittsburgh PA 15261, USA
  2. 2.Cystic Fibrosis Research Centre, Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh PA 15261, USA