Pflügers Archiv - European Journal of Physiology

, Volume 466, Issue 10, pp 1847–1857

On the road to bioartificial organs

Invited Review

DOI: 10.1007/s00424-014-1504-4

Cite this article as:
Ren, X. & Ott, H.C. Pflugers Arch - Eur J Physiol (2014) 466: 1847. doi:10.1007/s00424-014-1504-4

Abstract

Biological organs are highly orchestrated systems with well-coordinated positioning, grouping, and interaction of different cell types within their specialized extracellular environment. Bioartificial organs are intended to be functional replacements of native organs generated through bioengineering techniques and hold the potential to alleviate donor organ shortage for transplantation. The development, production, and evaluation of such bioartificial organs require synergistic efforts of biology, material science, engineering, and medicine. In this review, we highlight the emerging platforms enabling structured assembly of multiple cell types into functional grafts and discuss recent advances and challenges in the development of bioartificial organs, including cell sources, in vitro organ culture, in vivo evaluation, and clinical considerations.

Keywords

Bioartificial organs Decellularization Bioprinting Organoid Tissue engineering Organ engineering 

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Center for Regenerative MedicineMassachusetts General HospitalBostonUSA
  2. 2.Harvard Medical SchoolBostonUSA
  3. 3.Division of Thoracic Surgery, Department of SurgeryMassachusetts General HospitalBostonUSA
  4. 4.Harvard Stem Cell InstituteBostonUSA