Pflügers Archiv - European Journal of Physiology

, Volume 462, Issue 2, pp 195–208

Anoctamins

  • Karl Kunzelmann
  • Yuemin Tian
  • Joana Raquel Martins
  • Diana Faria
  • Patthara Kongsuphol
  • Jiraporn Ousingsawat
  • Frank Thevenod
  • Eleni Roussa
  • Jason Rock
  • Rainer Schreiber
Invited Review

DOI: 10.1007/s00424-011-0975-9

Cite this article as:
Kunzelmann, K., Tian, Y., Martins, J.R. et al. Pflugers Arch - Eur J Physiol (2011) 462: 195. doi:10.1007/s00424-011-0975-9

Abstract

Endogenous Ca2+-activated Cl channels (CaCC) demonstrate biophysical and pharmacological properties that are well represented in cells overexpressing anoctamin 1 (Ano 1, TMEM16A), a protein that has been identified recently as CaCC. Proteins of the anoctamin family (anoctamin 1–10, TMEM16A-K) are widely expressed. The number of reports demonstrating their physiological and clinical relevance is quickly rising. Anoctamins gain additional interest through their potential role in cell volume regulation and malignancy. Available data suggest that Ano 1 forms stable dimers and probably liaise with accessory proteins such as calmodulin or other anoctamins. In order to understand how anoctamins produce Ca2+-activated Cl currents, it will be necessary to obtain better insight into their molecular structure, interactions with partner proteins, and mode of activation.

Keywords

Ca2+-activated Cl currents CaCC TMEM16A Ano 1 Anoctamin TMEM16B TMEM16E TMEM16F TMEM16G TMEM16H TMEM16J TMEM16K Cystic fibrosis Proliferation Cancer Development, SHH 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Karl Kunzelmann
    • 1
  • Yuemin Tian
    • 1
  • Joana Raquel Martins
    • 1
  • Diana Faria
    • 1
  • Patthara Kongsuphol
    • 1
  • Jiraporn Ousingsawat
    • 1
  • Frank Thevenod
    • 2
  • Eleni Roussa
    • 3
  • Jason Rock
    • 4
  • Rainer Schreiber
    • 1
  1. 1.Institut für PhysiologieUniversität RegensburgRegensburgGermany
  2. 2.Lehrstuhl für Physiologie und Pathophysiologie, Fakultät für MedizinUniversität Witten/HerdeckeWittenGermany
  3. 3.Institut für Anatomie und Zellbiologie, Molekulare EmbryologieUniversität FreiburgFreiburg im BreisgauGermany
  4. 4.Department of Cell BiologyDuke University Medical CenterDurhamUSA

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