Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function

Invited Review

DOI: 10.1007/s00424-011-0951-4

Cite this article as:
McCain, M.L. & Parker, K.K. Pflugers Arch - Eur J Physiol (2011) 462: 89. doi:10.1007/s00424-011-0951-4

Abstract

Mechanotransduction refers to the conversion of mechanical forces into biochemical or electrical signals that initiate structural and functional remodeling in cells and tissues. The heart is a kinetic organ whose form changes considerably during development and disease, requiring cardiac myocytes to be mechanically durable and capable of fusing a variety of environmental signals on different time scales. During physiological growth, myocytes adaptively remodel to mechanical loads. Pathological stimuli can induce maladaptive remodeling. In both of these conditions, the cytoskeleton plays a pivotal role in both sensing mechanical stress and mediating structural remodeling and functional responses within the myocyte.

Keywords

Mechanotransduction Heart Cytoskeleton Cardiac sarcomere Cardiac myocytes Mechanosensitivity 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Disease Biophysics Group, Wyss Institute for Biologically Inspired EngineeringHarvard UniversityCambridgeUSA
  2. 2.School of Engineering and Applied SciencesHarvard UniversityCambridgeUSA

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