Pflügers Archiv - European Journal of Physiology

, Volume 460, Issue 2, pp 437–450

Transient receptor potential channelopathies

Molecular and Genomic Physiology

DOI: 10.1007/s00424-010-0788-2

Cite this article as:
Nilius, B. & Owsianik, G. Pflugers Arch - Eur J Physiol (2010) 460: 437. doi:10.1007/s00424-010-0788-2

Abstract

In the past years, several hereditary diseases caused by defects in transient receptor potential channels (TRP) genes have been described. This review summarizes our current knowledge about TRP channelopathies and their possible pathomechanisms. Based on available genetic indications, we will also describe several putative pathological conditions in which (mal)function of TRP channels could be anticipated.

Keywords

TRP channelsChannelopathiesDrug targetsHereditary diseasesSNPCation channelCalcium signallingCalciumMagnesium

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Laboratory Ion Channel Research, Department of Molecular Cell BiologyKU LeuvenLeuvenBelgium