Pflügers Archiv - European Journal of Physiology

, Volume 460, Issue 2, pp 307–320

KATP channelopathies in the pancreas

Integrative Physiology

DOI: 10.1007/s00424-009-0756-x

Cite this article as:
Remedi, M.S. & Koster, J.C. Pflugers Arch - Eur J Physiol (2010) 460: 307. doi:10.1007/s00424-009-0756-x


Adenosine-triphosphate-sensitive potassium channels (KATP) are regulated by adenosine nucleotides, and, thereby, couple cellular metabolism with electrical activity in multiple tissues including the pancreatic β-cell. The critical involvement of KATP in insulin secretion is confirmed by the demonstration that inactivating and activating mutations in KATP underlie persistent hyperinsulinemia and neonatal diabetes mellitus, respectively, in both animal models and humans. In addition, a common variant in KATP represents a risk factor in the etiology of type 2 diabetes. This review focuses on the mechanistic basis by which KATP mutations underlie insulin secretory disorders and the implications of these findings for successful clinical intervention.


Neonatal DiabetesHyperinsulinismDiazoxideSulfonylureaKir6.2SUR1

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Department of Cell Biology and PhysiologyWashington University School of MedicineSt. LouisUSA