Pflügers Archiv - European Journal of Physiology

, Volume 458, Issue 5, pp 953–967

The mammalian family of sterile 20p-like protein kinases

Signaling and Cell Physiology

DOI: 10.1007/s00424-009-0674-y

Cite this article as:
Delpire, E. Pflugers Arch - Eur J Physiol (2009) 458: 953. doi:10.1007/s00424-009-0674-y
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Abstract

Twenty-eight kinases found in mammalian genomes share similarity to the budding yeast kinase Ste20p. This review article examines the biological function of these mammalian Ste20 kinases. Some of them have conserved the Ste20p function of transducing extracellular signals to mitogen-activated kinases. Others affect ion transport, cell cycle, cytoskeleton organization, and program cell death. A number of molecular details involved in the activation of the kinases are discussed including autophosphorylation, substrate recognition, autoinhibition, dimerization, and substrate binding.

Keywords

Chloride transport Cell volume Cell cycle Cytoskeleton Protein kinase Signal transduction 

Abbreviations

CHK

Checkpoint kinase

ClC

Chloride channel, ClC family

DAPK

Death associated protein kinase

EGF

Epidermal growth factor

ERK

Extracellular signal-regulated kinase

GCK

Germinal center kinase

GCKR

GCK-related

GBP3

Guanylate binding protein 3

GLK

GCK-like kinase

HPK1

Hematopoietic progenitor kinase 1

JIK

JNK inhibitory kinase

JNK

c-jun N-terminal kinase

KCC

K-Cl cotransporter

KFC

Kinase from chicken

KHS

Kinase homologous to SPS1/Ste20

KRS

Kinase responsive to stress

LIMK

LIM motif-containing kinase

LOK

Lymphocyte oriented kinase

LOSK

Long Ste20-like kinase

MAPK

Mitogen-activated kinase

MAP2K

Mitogen-activated kinase kinase

MAP3K

Mitogen-activated kinase kinase kinase

MAP4K

Mitogen-activated kinase kinase kinase kinase

MASK

Mst3 and SOK1-related kinase

MEK

Kinase

MEKK

Kinase kinase

Mink

Mishappen/NIK-related kinase

Mst

Mammalian sterile 20

NESK

Nck-interacting kinase-like embryo-specific kinase

NIK

Nck-interacting kinase

NKCC

Na-K-2Cl cotransporter

NRK

NIK-related kinase

OSR

Oxidative stress response

PAK

p21-activated kinase

PDGF

Platelet-derived growth factor

PKA

Protein kinase A

PKC

Protein kinase C

PASK

Proline alanine rich Ste20 kinase

PSK

Prostate-derived Ste20 kinase

SLK

Synthetic lethal kinase

SPAK

Ste20-related proline alanine rich kinase

Ste

Sterile

S/T

Serine/threonine kinases

TAO

Thousand and one, as for the thousand and one amino acid of TAO1

TNIK

Traf and Nck-interacting kinase

TNF

Tumor necrosis factor

TRAF

TNF receptor-associated factor

WNK

With no lysine kinase

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of AnesthesiologyVanderbilt University Medical CenterNashvilleUSA

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