Signaling and Cell Physiology

Pflügers Archiv - European Journal of Physiology

, Volume 458, Issue 5, pp 953-967

First online:

The mammalian family of sterile 20p-like protein kinases

  • Eric DelpireAffiliated withDepartment of Anesthesiology, Vanderbilt University Medical Center Email author 

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Twenty-eight kinases found in mammalian genomes share similarity to the budding yeast kinase Ste20p. This review article examines the biological function of these mammalian Ste20 kinases. Some of them have conserved the Ste20p function of transducing extracellular signals to mitogen-activated kinases. Others affect ion transport, cell cycle, cytoskeleton organization, and program cell death. A number of molecular details involved in the activation of the kinases are discussed including autophosphorylation, substrate recognition, autoinhibition, dimerization, and substrate binding.


Chloride transport Cell volume Cell cycle Cytoskeleton Protein kinase Signal transduction