Pflügers Archiv - European Journal of Physiology

, Volume 457, Issue 3, pp 635–644

The Na/K-ATPase/Src complex and cardiotonic steroid-activated protein kinase cascades

Authors

  • Zhichuan Li
    • Department of Physiology and PharmacologyUniversity of Toledo College of Medicine, Health Science Campus
    • Department of Physiology and PharmacologyUniversity of Toledo College of Medicine, Health Science Campus
Ion Channels

DOI: 10.1007/s00424-008-0470-0

Cite this article as:
Li, Z. & Xie, Z. Pflugers Arch - Eur J Physiol (2009) 457: 635. doi:10.1007/s00424-008-0470-0

Abstract

The Na/K-ATPase was discovered by Skou in 1957. Since then, the efforts of numerous investigators have led to the following conclusions: (a) This enzyme is indeed the molecular machine for the ATP-dependent and -coupled transport of Na+ and K+ across the plasma membrane of a living cell in which such a process (sodium pump) is detected. (b) The Na/K-ATPase is also an important signal transducer that not only interacts and regulates protein kinases, but also functions as a scaffold, capable of bringing the affector and effectors together to form functional signalosomes. This minireview discusses the interaction between the Na/K-ATPase and Src to illustrate how a P-type ATPase can act as a receptor, converting a ligand-binding signal to the activation of protein kinase cascades and the generation of second messengers.

Keywords

Na/K-ATPaseTyrosine kinaseProtein phosphorylationReceptorProtein kinase

Abbreviations

A domain

activation domain

ADPKD

autosomal dominant polycystic kidney disease

CD2

second cytosolic domain

CD3

third cytosolic domain

CTS

cardiotonic steroids

EGFR

epidermal growth factor receptor

ERK

extracellular signal-regulated protein kinase

FAK

focal adhesion kinase

FRET

fluorescence resonance energy transfer

GST

glutathione-S-transferase

GPCR

G protein-coupled receptor

IP3

inositol triphosphate

IP3R

IP3 receptor

IRBIT

IP3R binding protein released with inositol 1,4,5-trisphosphate

MBG

marinobufagenin

N domain

nucleotide binding domain

P domain

phosphorylation domain

PI3K

phosphatidylinositol 3-kinase

PKC

protein kinase C

PLC

phospholipase C

PTKs

protein tyrosine kinases

ROMK

renal outer medullary K channel

SERCA

sarcoplasmic reticulum Ca-ATPase

Copyright information

© Springer-Verlag 2008