Voltage-gated calcium channels in chronic pain: emerging role of alternative splicing

Invited Review

DOI: 10.1007/s00424-007-0390-4

Cite this article as:
Swayne, L.A. & Bourinet, E. Pflugers Arch - Eur J Physiol (2008) 456: 459. doi:10.1007/s00424-007-0390-4


N- and T-type voltage-gated calcium channels are key established players in chronic pain. Current work suggests that alternative splicing of these channels constitutes an important aspect in the investigation of their roles in the pathogenesis of chronic pain. Recent N-type channel studies describe a nociceptor-enriched alternatively spliced module responsible for voltage-independent G protein modulation and internalization, which is implicated in the control of distinct nociceptive pathways. On the contrary, although a large body of work has demonstrated that peripheral Cav3.2-encoded T-type currents are involved in several types of chronic pain, little is known with respect to the expression of numerous newly discovered splice variants in specific pain pathways. The elucidation of the new layers of molecular complexity uncovered in N- and T-type channel splice variants and their respective locations and roles in different pain pathways will allow for the development of better therapeutic strategies for the treatment of chronic pain.


Pain Calcium channel Dorsal root ganglion Dorsal horn Neurotransmission 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Département de PhysiologieInstitut de Génomique FonctionnelleMontpellierFrance
  2. 2.CNRS UMR5203, INSERM U661, IFR3Universités Montpellier I and IIMontpellierFrance