Pflügers Archiv - European Journal of Physiology

, 455:5

Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases

Authors

  • Yuntao S. Mao
    • Department of PhysiologyUniversity of Texas Southwestern Medical Center
    • Department of PhysiologyUniversity of Texas Southwestern Medical Center
Invited Review

DOI: 10.1007/s00424-007-0286-3

Cite this article as:
Mao, Y.S. & Yin, H.L. Pflugers Arch - Eur J Physiol (2007) 455: 5. doi:10.1007/s00424-007-0286-3

Abstract

Phosphatidylinositol (4,5)-bisphosphate (PIP2) is an important lipid mediator that has multiple regulatory functions. There is now increasing evidence that the phosphatidylinositol 4-phosphate 5 kinases (PIP5Ks), which synthesize PIP2, are regulated spatially and temporally and that they have isoform-specific functions and regulations. This review will summarize the highlights of recent developments in understanding how the three major PIP5K isoforms regulate the actin cytoskeleton and other important cellular processes.

Keywords

PIP2PIP5KActin cytoskeletonArf6EndocytosisPhagocytosis

Copyright information

© Springer-Verlag 2007