Pflügers Archiv

, Volume 453, Issue 1, pp 11–22

What’s new in ion transports in the cochlea?

  • Vincent Couloigner
  • Olivier Sterkers
  • Evelyne Ferrary
Invited Review

DOI: 10.1007/s00424-006-0103-4

Cite this article as:
Couloigner, V., Sterkers, O. & Ferrary, E. Pflugers Arch - Eur J Physiol (2006) 453: 11. doi:10.1007/s00424-006-0103-4

Abstract

Recent advances in the field of the physiology of inner ear fluids permitted the characterization of the molecular mechanisms involved in critical processes such as the absorption of K+ through cochlear sensory hair cells (mechanoelectrical transduction) or the secretion of K+ by marginal cells of the stria vascularis. In addition, new pathways for ion circulations were evidenced. Mutations of transporters involved in some of these pathways, especially in K+ recycling through gap junction systems, and in local pH regulation, are among the most frequent etiologies of genetic deafness in humans.

Keywords

Inner ear fluids Potassium Sodium Acid-base Endolymph Connexin Hearing Deafness 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Vincent Couloigner
    • 1
    • 2
  • Olivier Sterkers
    • 1
    • 3
  • Evelyne Ferrary
    • 1
    • 3
  1. 1.Inserm EMI U-0112Faculté Xavier BichatParisFrance
  2. 2.Pediatric ENT DepartmentHôpital Necker–Enfants MaladesParisFrance
  3. 3.ENT DepartmentHôpital BeaujonParisFrance

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