, Volume 453, Issue 1, pp 11-22
Date: 14 Jun 2006

What’s new in ion transports in the cochlea?

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Abstract

Recent advances in the field of the physiology of inner ear fluids permitted the characterization of the molecular mechanisms involved in critical processes such as the absorption of K+ through cochlear sensory hair cells (mechanoelectrical transduction) or the secretion of K+ by marginal cells of the stria vascularis. In addition, new pathways for ion circulations were evidenced. Mutations of transporters involved in some of these pathways, especially in K+ recycling through gap junction systems, and in local pH regulation, are among the most frequent etiologies of genetic deafness in humans.