What’s new in ion transports in the cochlea?
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- Couloigner, V., Sterkers, O. & Ferrary, E. Pflugers Arch - Eur J Physiol (2006) 453: 11. doi:10.1007/s00424-006-0103-4
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Recent advances in the field of the physiology of inner ear fluids permitted the characterization of the molecular mechanisms involved in critical processes such as the absorption of K+ through cochlear sensory hair cells (mechanoelectrical transduction) or the secretion of K+ by marginal cells of the stria vascularis. In addition, new pathways for ion circulations were evidenced. Mutations of transporters involved in some of these pathways, especially in K+ recycling through gap junction systems, and in local pH regulation, are among the most frequent etiologies of genetic deafness in humans.