Pflügers Archiv

, Volume 452, Issue 5, pp 501–512

Biophysics of P2X receptors

  • Terrance M. Egan
  • Damien S. K. Samways
  • Zhiyuan Li
Invited Review

DOI: 10.1007/s00424-006-0078-1

Cite this article as:
Egan, T.M., Samways, D.S.K. & Li, Z. Pflugers Arch - Eur J Physiol (2006) 452: 501. doi:10.1007/s00424-006-0078-1

Abstract

The P2X receptor is the baby brother of the ligand-gated ion channel super-family. An understanding of its role in human physiology is still developing, and no one truly knows how it works to transport ions across the membrane. In this study, we review some aspects of P2X channel biophysics, concentrating on ion permeation and gating. P2X channels transport both small and large cations and anions across cell membranes in a manner that depends on both the subunit composition of the receptor and the experimental conditions. We describe the pore properties of wild-type receptors and use the altered phenotypes of mutant receptors to point the way towards a structural model of the pore.

Keywords

ATPIonotropic receptorPurinergic receptorP2XPermeabilityConductanceGating

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Terrance M. Egan
    • 1
  • Damien S. K. Samways
    • 1
  • Zhiyuan Li
    • 1
  1. 1.Department of Pharmacological and Physiological ScienceSaint Louis University School of MedicineSt. LouisUSA