Invited Review

Pflügers Archiv

, Volume 451, Issue 1, pp 72-80

First online:

The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance

  • Alexander DietrichAffiliated withInstitut für Pharmakologie und Toxikologie, PhilippsUniversität Marburg Email author 
  • , Hermann KalwaAffiliated withInstitut für Pharmakologie und Toxikologie, PhilippsUniversität Marburg
  • , Benjamin R. RostAffiliated withInstitut für Pharmakologie und Toxikologie, PhilippsUniversität Marburg
  • , Thomas GudermannAffiliated withInstitut für Pharmakologie und Toxikologie, PhilippsUniversität Marburg

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Abstract

Among the “classical” or “canonical” transient receptor potential (TRPC) family, the TRPC3, -6, and -7 channels share 75% amino acid identity and are gated by exposure to diacylglycerol. TRPC3, TRPC6, and TRPC7 interact physically and coassemble to form functional tetrameric channels. This review focuses on the TRPC3/6/7 subfamily and describes their functional properties and regulation as homomers obtained from overexpression studies in cell lines. It also summarizes their heteromultimerization potential in vitro and in vivo and presents initial data concerning their physiological functions analyzed in isolated tissues with downregulated channel activity and gene-deficient mouse models.

Keywords

DAG-sensitive TRPC3, TRPC6, TRPC7 Non-selective cation channels Functional characterization Physiological function Smooth muscle cells Pulmonary arterial hypertension Bayliss effect