Pflügers Archiv

, Volume 451, Issue 1, pp 204–211

The mammalian melastatin-related transient receptor potential cation channels: an overview

Invited Review

DOI: 10.1007/s00424-005-1428-0

Cite this article as:
Kraft, R. & Harteneck, C. Pflugers Arch - Eur J Physiol (2005) 451: 204. doi:10.1007/s00424-005-1428-0

Abstract

The mammalian melastatin-related transient receptor potential (TRPM) subfamily contains eight members. TRPM proteins, consisting of six putative transmembrane domains and intracellular N and C termini, form monovalent-permeable cation channels with variable selectivity for Ca2+, Mg2+ and other divalent cations. Some functions are linked to their individual cation selectivity: the highly divalent-permeable cation channels TRPM6 and TRPM7 are involved in the control of Mg2+ influx, whereas the Ca2+-impermeable channels TRPM4 and TRPM5 modulate cellular Ca2+ entry by determining the membrane potential. TRPM2, TRPM3 and TRPM8 mediate a direct influx of Ca2+ in response to specific stimuli. Electrophysiological properties of the founding member, melastatin (TRPM1), are unexplored. The individual TRPM members are activated by different stimuli, including voltage, Ca2+, temperature, cell swelling, lipid compounds and other endogenous or exogenous ligands. This review summarizes molecular features, activation mechanisms, biophysical properties and modulators of TRPM channels.

Keywords

Transient receptor potentialMelastatinMagnesium homeostasisCAN channelsCation channelsVoltage-gatedProliferationDifferentiation

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Carl-Ludwig-Institut für PhysiologieUniversität LeipzigLeipzigGermany
  2. 2.Institut für PharmakologieCharité Campus Benjamin FranklinBerlinGermany