Pflügers Archiv

, Volume 447, Issue 5, pp 566–570

The sodium bile salt cotransport family SLC10

The ABC of Solute Carriers Guest Editor: Matthias A. Hediger

DOI: 10.1007/s00424-003-1130-z

Cite this article as:
Hagenbuch, B. & Dawson, P. Pflugers Arch - Eur J Physiol (2004) 447: 566. doi:10.1007/s00424-003-1130-z

Abstract

The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known. The Na+/taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile salt transporter (ASBT; SLC10A2) are critical components of the enterohepatic circulation of bile salts. NTCP and ASBT are cotransporters that mediate sodium-dependent, electrogenic uptake of mainly bile salts into hepatocytes (NTCP), biliary epithelial cells, ileal enterocytes and renal proximal tubular cells (ASBT).

Keywords

Bile saltEnterohepatic circulationNTCPASBTLiverIntestineProximal tubuleCotransport

Copyright information

© Springer-Verlag  2004

Authors and Affiliations

  1. 1.Division of Clinical Pharmacology and Toxicology, Department of MedicineUniversity HospitalZurichSwitzerland
  2. 2.Wake Forest University School of MedicineWinston-SalemUSA