The ABC of Solute Carriers Guest Editor: Matthias A. Hediger

Pflügers Archiv

, Volume 447, Issue 5, pp 629-635

First online:

Organic anion transport is the primary function of the SLC17/type I phosphate transporter family

  • Richard J. ReimerAffiliated withDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine Email author 
  • , Robert H. EdwardsAffiliated withDepartments of Neurology and Physiology, Graduate Programs in Neuroscience and Cell Biology, University of California

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Abstract

Recently, molecular studies have determined that the SLC17/type I phosphate transporters, a family of proteins initially characterized as phosphate carriers, mediate the transport of organic anions. While their role in phosphate transport remains uncertain, it is now clear that the transport of organic anions facilitated by this family of proteins is involved in diverse processes ranging from the vesicular storage of the neurotransmitter glutamate to the degradation and metabolism of glycoproteins.

Keywords

Neurotransmitter transporter Organic anion transport Sialin Type I phosphate transporter Vesicular glutamate transporter