The sodium/calcium exchanger family—SLC8
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- Quednau, B.D., Nicoll, D.A. & Philipson, K.D. Pflugers Arch - Eur J Physiol (2004) 447: 543. doi:10.1007/s00424-003-1065-4
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The Na+/Ca2+ exchanger gene family encompasses three distinct proteins, NCX1, NCX2, and NCX3, which mediate cellular Ca2+ efflux and thus contribute to intracellular Ca2+ homeostasis. NCX1 is expressed ubiquitously while NCX2 and NCX3 are limited to brain and skeletal muscle. NCX1 exchanges 3 extracellular Na+ for 1 intracellular Ca2+. In addition to transporting Na+ and Ca2+, NCX1 activity is also regulated by these cations. NCX1 is especially important in regulating cardiac contractility.