, Volume 447, Issue 5, pp 543-548
Date: 07 May 2003

The sodium/calcium exchanger family—SLC8

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The Na+/Ca2+ exchanger gene family encompasses three distinct proteins, NCX1, NCX2, and NCX3, which mediate cellular Ca2+ efflux and thus contribute to intracellular Ca2+ homeostasis. NCX1 is expressed ubiquitously while NCX2 and NCX3 are limited to brain and skeletal muscle. NCX1 exchanges 3 extracellular Na+ for 1 intracellular Ca2+. In addition to transporting Na+ and Ca2+, NCX1 activity is also regulated by these cations. NCX1 is especially important in regulating cardiac contractility.