Pflügers Archiv

, Volume 447, Issue 5, pp 543–548

The sodium/calcium exchanger family—SLC8

  • Beate D. Quednau
  • Debora A. Nicoll
  • Kenneth D. Philipson
The ABC of Solute Carriers Guest Editor: Matthias A. Hediger

DOI: 10.1007/s00424-003-1065-4

Cite this article as:
Quednau, B.D., Nicoll, D.A. & Philipson, K.D. Pflugers Arch - Eur J Physiol (2004) 447: 543. doi:10.1007/s00424-003-1065-4

Abstract

The Na+/Ca2+ exchanger gene family encompasses three distinct proteins, NCX1, NCX2, and NCX3, which mediate cellular Ca2+ efflux and thus contribute to intracellular Ca2+ homeostasis. NCX1 is expressed ubiquitously while NCX2 and NCX3 are limited to brain and skeletal muscle. NCX1 exchanges 3 extracellular Na+ for 1 intracellular Ca2+. In addition to transporting Na+ and Ca2+, NCX1 activity is also regulated by these cations. NCX1 is especially important in regulating cardiac contractility.

Keywords

Calcium Sodium Antiport Myocardium Sodium-calcium exchange 

Copyright information

© Springer-Verlag  2004

Authors and Affiliations

  • Beate D. Quednau
    • 1
    • 2
  • Debora A. Nicoll
    • 1
    • 2
  • Kenneth D. Philipson
    • 1
    • 2
    • 3
  1. 1.Department of Physiology, David Geffen School of MedicineUniversity of California, Los AngelesLos AngelesUSA
  2. 2.Cardiovascular Research Laboratories, David Geffen School of MedicineUniversity of California Los AngelesLos AngelesUSA
  3. 3.Department of Medicine, David Geffen School of MedicineUniversity of California Los AngelesLos AngelesUSA