Langenbeck's Archives of Surgery

, Volume 385, Issue 8, pp 521–525

Benign solitary fibrous tumour of the thigh: morphological, chromosomal and differential diagnostic aspects

Authors

  • Michael Krismann
    • Institute of Pathology, Professional Associations' Clinic Bergmannsheil Bochum, University Clinic, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany
  • Heiner Adams
    • Institute of Pathology, Professional Associations' Clinic Bergmannsheil Bochum, University Clinic, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany
  • Malgorzata Jaworska
    • Institute of Pathology, Professional Associations' Clinic Bergmannsheil Bochum, University Clinic, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany
  • Klaus-Michael Müller
    • Institute of Pathology, Professional Associations' Clinic Bergmannsheil Bochum, University Clinic, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany
  • Georg Johnen
    • Institute of Pathology, Professional Associations' Clinic Bergmannsheil Bochum, University Clinic, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany
Original Article

DOI: 10.1007/s004230000167

Cite this article as:
Krismann, M., Adams, H., Jaworska, M. et al. Langenbeck's Arch Surg (2000) 385: 521. doi:10.1007/s004230000167

Abstract.

Solitary fibrous tumours (SFTs) are rare and usually benign neoplasms of mesenchymal origin that are often found in the visceral pleura (fibrous pleural tumour, FPT) or other serosal surfaces. They have also been found in soft tissues. We report the case of an SFT localised in the thigh of an 86-year-old woman. The tumour specimen was examined morphologically, immunohistochemically and molecular genetically, using comparative genomic hybridisation (CGH). The latter detects unbalanced chromosomal alterations in human neoplasms by competitive nucleic acid hybridisation and consecutive computer image analysis. The tumour consists of fibroblast-like cells, arranged in a typical "patternless pattern". Immunohistochemically, the tumour stained positively for vimentin, CD34, CD99, and focally for actin and desmin. No reaction occurred with keratin or S100 protein antibodies. CGH detected a single loss on chromosome 13q.

Solitary fibrous tumour Thigh Immunohistochemistry Comparative genomic hybridisation

Copyright information

© Springer-Verlag 2000