Langenbeck's Archives of Surgery

, Volume 399, Issue 5, pp 589–594

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in recurrent epithelial ovarian cancer with peritoneal metastases: a single centre experience

  • Ingmar Königsrainer
  • Philipp Horvath
  • Florian Struller
  • Eva Maria Grischke
  • Diethelm Wallwiener
  • Alfred Königsrainer
  • Stefan Beckert
Original Article

DOI: 10.1007/s00423-014-1207-5

Cite this article as:
Königsrainer, I., Horvath, P., Struller, F. et al. Langenbecks Arch Surg (2014) 399: 589. doi:10.1007/s00423-014-1207-5

Abstract

Background

This investigation aims to assess morbidity, mortality and postoperative outcomes of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in recurrent epithelial ovarian cancer (REOC) with peritoneal metastases (PM).

Methods

Consecutive patients with radiographic evidence of REOC with PM were scheduled for CRS and HIPEC at the Comprehensive Cancer Center, University Hospital Tübingen, Germany. Clinical data were retrospectively analyzed.

Results

In total, 90 patients were analyzed. Complete cytoreduction and HIPEC could be performed in 69 % of patients. When categorizing patients with respect to the completeness of cytoreduction (CC-0/1 vs CC-2/3), there was no difference considering baseline demographic characteristics. Cumulative morbidity was 42 %. Morbidity rates did not statistically differ between CC-0/1 patients with HIPEC and CC-2/3 patients without HIPEC. No surgery-related and 90-day postoperative mortality was observed. In CC-0/1 patients, median overall survival was 35 months as opposed to 14 months in CC-2/3 patients. There was no difference in survival with respect to the peritoneal carcinomatosis index (PCI) as long as complete cytoreduction could be achieved.

Conclusions

CRS and HIPEC can be performed with acceptable morbidity and low mortality in specialized centres. Our data do not suggest that HIPEC necessarily increases the risk of postoperative adverse events.

Keywords

Peritoneal surface malignancyHIPECRecurrent ovarian cancer

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Ingmar Königsrainer
    • 1
  • Philipp Horvath
    • 1
  • Florian Struller
    • 1
  • Eva Maria Grischke
    • 2
  • Diethelm Wallwiener
    • 2
  • Alfred Königsrainer
    • 1
  • Stefan Beckert
    • 1
  1. 1.Department of General, Visceral and Transplant SurgeryUniversity of Tübingen, Comprehensive Cancer CenterTübingenGermany
  2. 2.Department of GynecologyUniversity of Tübingen, Comprehensive Cancer CenterTübingenGermany