Langenbeck's Archives of Surgery

, Volume 393, Issue 3, pp 275–280

Serum levels of interleukin-1 receptor antagonist (IL-1ra) in thyroid cancer patients

Authors

    • Department of Endocrine and General SurgeryMedical University of Łódź, Copernicus Memorial Hospital
    • Department of General, Visceral and Transplantation Surgery, Charité, University MedicineCampus Virchow Clinical Centre
  • Tomasz Stępień
    • Department of Endocrine and General SurgeryMedical University of Łódź, Copernicus Memorial Hospital
  • Krzysztof Kuzdak
    • Department of Endocrine and General SurgeryMedical University of Łódź, Copernicus Memorial Hospital
  • Henryk Stępień
    • Department of ImmunoendocrinologyMedical University of Łódź
  • Roman Krupiński
    • Department of Endocrine and General SurgeryMedical University of Łódź, Copernicus Memorial Hospital
  • Daniel Seehofer
    • Department of General, Visceral and Transplantation Surgery, Charité, University MedicineCampus Virchow Clinical Centre
  • Nada Rayes
    • Department of General, Visceral and Transplantation Surgery, Charité, University MedicineCampus Virchow Clinical Centre
  • Frank Ulrich
    • Department of General, Visceral and Transplantation Surgery, Charité, University MedicineCampus Virchow Clinical Centre
Original Article

DOI: 10.1007/s00423-007-0251-9

Cite this article as:
Niedźwiecki, S., Stępień, T., Kuzdak, K. et al. Langenbecks Arch Surg (2008) 393: 275. doi:10.1007/s00423-007-0251-9

Abstract

Background and aims

There is growing evidence that cytokines and their antagonists are important in the pathogenesis of various malignancies. While there are several reports on interleukin-1 receptor antagonist (IL-1ra) gene polymorphism and tissue expression, there is only little data available on the impact of IL-1ra serum levels. Therefore, we performed a prospective study, analyzing IL-1ra in thyroid cancer patients.

Materials and methods

We measured preoperative IL-1ra serum levels of 52 consecutive patients with thyroid cancer, 15 with benign adenoma and 27 healthy volunteers. The final histological diagnosis revealed 21 patients with papillary and 8 patients with follicular carcinoma (FTC), while 12 cases of medullary and 11 cases of anaplastic carcinoma (ATC) were observed.

Results

Compared to the control group, serum concentrations of IL-1ra were significantly higher in ATC and FTC patients. Concerning gender differences, this effect reached significance only in women with ATC and FTC. Except for the stage IV disease in ATC, there was no correlation between IL-1ra levels and International Union Against Cancer staging.

Conclusion

The findings of our study indicate that IL-1ra may play an important role in the development of ATC and FTC. Future efforts should focus on the possible application of IL-1ra as a biomarker for the above-mentioned thyroid malignancies.

Keywords

Interleukin-1 receptor antagonistThyroid cancer

Copyright information

© Springer-Verlag 2007