Current Concepts in Clinical Surgery

Langenbeck's Archives of Surgery

, Volume 390, Issue 6, pp 503-509

First online:

Standards of medical treatment and nutrition in Crohn’s disease

  • Britta SiegmundAffiliated withMedizinische Klinik I, Charité Universitätsmedizin Berlin
  • , Martin ZeitzAffiliated withMedizinische Klinik I, Charité Universitätsmedizin Berlin Email author 

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Abstract

Crohn’s disease is a condition of chronic inflammation potentially involving any location of the alimentary tract from mouth to anus but with a propensity for the distal small bowel and proximal large bowel. Frequent complications include stricture and fistula. Numerous extra-intestinal manifestations may also be present. The aetiology of Crohn’s disease is incompletely understood, and therapy, although generally effective in alleviating the symptoms, is not curative. Due to the heterogeneity of the disease a major need for the therapeutic approach is the ability to define subgroups with distinct characteristics. However, with regard to the heterogeneity of demographic, anatomic and disease behaviour characteristics, distilling the numerous possible phenotypes in simple categories is a formidable task. In the present review the focus will be on clinically relevant situations providing therapeutic algorithms according to international guidelines.

Keywords

Crohn’s disease Therapy Immunosuppressive agents 5-Aminosalicylates Corticosteroids Nutrition