Biological Cybernetics

, 103:43

Intrinsic variability of latency to first-spike

Authors

    • Centre de Recherche en Epistémologie Appliquée, UMR 7656, Ecole Polytechnique, CNRS
  • Thieullen Michèle
    • Laboratoire de Probabilités et Modèles Aléatoires (LPMA), UMR 7599, CNRS
  • Pakdaman Khashayar
    • Institut Jacques Monod (IJM), UMR 7592, CNRS
Original Paper

DOI: 10.1007/s00422-010-0384-8

Cite this article as:
Gilles, W., Michèle, T. & Khashayar, P. Biol Cybern (2010) 103: 43. doi:10.1007/s00422-010-0384-8

Abstract

The assessment of the variability of neuronal spike timing is fundamental to gain understanding of latency coding. Based on recent mathematical results, we investigate theoretically the impact of channel noise on latency variability. For large numbers of ion channels, we derive the asymptotic distribution of latency, together with an explicit expression for its variance. Consequences in terms of information processing are studied with Fisher information in the Morris–Lecar model. A competition between sensitivity to input and precision is responsible for favoring two distinct regimes of latencies.

Keywords

Latency codingChannel noiseFisher informationMorris–Lecar model

Copyright information

© Springer-Verlag 2010