Biological Cybernetics

, Volume 98, Issue 2, pp 171–184

Physiology-based modeling of cortical auditory evoked potentials

Original Paper

DOI: 10.1007/s00422-007-0201-1

Cite this article as:
Kerr, C.C., Rennie, C.J. & Robinson, P.A. Biol Cybern (2008) 98: 171. doi:10.1007/s00422-007-0201-1


Evoked potentials are the transient electrical responses caused by changes in the brain following stimuli. This work uses a physiology-based continuum model of neuronal activity in the human brain to calculate theoretical cortical auditory evoked potentials (CAEPs) from the model’s linearized response. These are fitted to experimental data, allowing the fitted parameters to be related to brain physiology. This approach yields excellent fits to CAEP data, which can then be compared to fits of EEG spectra. It is shown that the differences between resting eyes-open EEG and standard CAEPs can be explained by changes in the physiology of populations of neurons in corticothalamic pathways, with notable similarities to certain aspects of slow-wave sleep. This pilot study demonstrates the ability of our model-based fitting method to provide information on the underlying physiology of the brain that is not available using standard methods.


Auditory evoked potential Brain modeling Corticothalamic Physiological parameters Brain activity analysis EEG 

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • C. C. Kerr
    • 1
    • 2
  • C. J. Rennie
    • 1
    • 2
    • 3
  • P. A. Robinson
    • 1
    • 2
    • 4
  1. 1.School of PhysicsUniversity of SydneySydneyAustralia
  2. 2.Brain Dynamics CenterWestmead HospitalWestmeadAustralia
  3. 3.Department of Medical PhysicsWestmead HospitalWestmeadAustralia
  4. 4.Faculty of MedicineUniversity of SydneySydneyAustralia

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