Biological Cybernetics

, Volume 95, Issue 2, pp 113–121

A Biophysical Basis for the Inter-spike Interaction of Spike-timing-dependent Plasticity

  • Neel T. Shah
  • Luk Chong Yeung
  • Leon N. Cooper
  • Yidao Cai
  • Harel Z. Shouval
Original Paper

DOI: 10.1007/s00422-006-0071-y

Cite this article as:
Shah, N.T., Yeung, L.C., Cooper, L.N. et al. Biol Cybern (2006) 95: 113. doi:10.1007/s00422-006-0071-y

Abstract

Although spike-timing-dependent plasticity (STDP) is well characterized when pre- and postsynaptic spikes are paired with a given time lag, how this generalizes for more complex spike-trains is unclear. Recent experiments demonstrate that contributions to synaptic plasticity from different spike pairs within a spike train do not add linearly. In the visual cortex conditioning with spike triplets shows that the effect of the first spike pair dominates over the second. Using a previously proposed calcium-dependent plasticity model, we show that short-term synaptic dynamics and interaction between successive back-propagating action potentials (BPAP) may jointly account for the nonlinearities observed. Paired-pulse depression and attenuation of BPAPs are incorporated into the model through the use-dependent depletion of pre- and postsynaptic resources, respectively. Simulations suggest that these processes may play critical roles in determining how STDP operates in the context of natural spike-trains.

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Neel T. Shah
    • 1
  • Luk Chong Yeung
    • 1
    • 2
    • 3
  • Leon N. Cooper
    • 1
    • 2
    • 3
  • Yidao Cai
    • 4
  • Harel Z. Shouval
    • 1
    • 4
  1. 1.Institute for Brain and Neural SystemsBrown UniversityProvidenceUSA
  2. 2.Department of PhysicsBrown UniversityProvidenceUSA
  3. 3.Department of NeuroscienceBrown UniversityProvidenceUSA
  4. 4.Department of Neurobiology and AnatomyThe University of Texas Medical School at HoustonHoustonUSA