Vascular endothelial growth factor in exercising humans under different environmental conditions

  • Hanns-Christian Gunga
  • Karl Kirsch
  • Lothar Röcker
  • Claus Behn
  • Eberhard Koralewski
  • Eliseo Hibert Davila
  • Manuel Ivan Estrada
  • Bernd Johannes
  • Peter Wittels
  • Wolfgang Jelkmann
ORIGINAL ARTICLE

DOI: 10.1007/s004210050541

Cite this article as:
Gunga, HC., Kirsch, K., Röcker, L. et al. Eur J Appl Physiol (1999) 79: 484. doi:10.1007/s004210050541

Abstract

It was the aim of this study to investigate the time course of changes in the serum concentrations of vascular endothelial growth factor (VEGF) during a regular survival training programme combined with food and fluid deprivation and during a high altitude marathon run. We studied soldiers of the Austrian Special Forces performing survival training at sea-level and marathon runners of the Posta Atletica who crossed the border between Chile and Argentina at altitudes up to 4722 m. Baseline data collected before the 1-week of survival training showed that the soldiers had normal VEGF [n=8, 246.7 (SD 118.5) pg · ml−1] serum concentrations which remained unchanged during the course of the study. Before the high altitude marathon the subjects showed normal VEGF serum concentrations [178 (SD 84.5) pg · ml−1]. After the run VEGF concentrations were found to be significantly decreased [41.0 (SD 41.6) pg · ml−1, P < 0.01]. It was concluded that prolonged physical stress during normobaric-normoxia did not alter the VEGF concentrations whereas during severe hypobaric-hypoxia decreased VEGF serum concentrations were measured, at least temporarily, after prolonged physical exercise which might have been due to changes in production, release, removal and/or binding of circulating VEGF.

Key words Vascular endothelial growth factor Vascularisation Survival training Marathon running High altitude 

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Hanns-Christian Gunga
    • 1
  • Karl Kirsch
    • 1
  • Lothar Röcker
    • 1
  • Claus Behn
    • 2
  • Eberhard Koralewski
    • 1
  • Eliseo Hibert Davila
    • 2
  • Manuel Ivan Estrada
    • 2
  • Bernd Johannes
    • 1
  • Peter Wittels
    • 4
  • Wolfgang Jelkmann
    • 3
  1. 1.Freie Universität Berlin, Physiologisches Institut, Arnimallee 22, D-14 195 Berlin, GermanyDE
  2. 2.Departamento de Fisiología y Biofìsica, Centro Estudios Actividad Física (CEAFI), Facultad de Medicina, Santiago, ChileCL
  3. 3.Institut für Physiologie, Medizinische Universität Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, GermanyDE
  4. 4.Research Study Group on Physical Performance, Army Hospital, Brünnerstraße 238, A-1210 Vienna, AustriaAT